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Donate $1900.00 and receive a science repository containing lectures on complete college level courses such as: biology, chemistry - general and organic, biochemistry, anatomy and physiology, immunology and etc.(about 2 years worth). Can be viewed on cell phone, and computer or tv via usb.

Immunotherapy Project

Strategies of immunotherapy

1. Activate a section of the immune system that the body can manage.

2. Turn off the section of the immune system that is overreacting.

Immunotherapy is a medical term defined as the "treatment of disease by inducing, enhancing, or suppressing an immune response". Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies.

The active agents of immunotherapy are collectively called immunomodulators. They are a diverse array of recombinant, synthetic and natural preparations, often cytokines. Some of these substances, such as granulocyte colony-stimulating factor (G-CSF), interferons, imiquimod and cellular membrane fractions from bacteria are already licensed for use in patients. Others including IL-2, IL-7, IL-12, various chemokines, synthetic cytosine phosphate-guanosine (CpG) oligodeoxynucleotides and glucans are currently being investigated extensively in clinical and preclinical studies. Immunomodulatory regimens offer an attractive approach as they often have fewer side effects than existing drugs, including less potential for creating resistance in microbial diseases.

Agent- Example

Interleukins- IL-2, IL-7, IL-12
Cytokines- Interferons, G-CSF, Imiquimod
Chemokines- CCL3, CCL26, CXCL7
Other- cytosine phosphate-guanosine, oligodeoxynucleotides, glucans

Cell based Immunotherapies are proven to be effective for some cancers. Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells (NK Cell), cytotoxic T lymphocytes (CTL), etc., work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of the tumor due to mutation.

Drug - Mechanism
abatacept - T-cell costimulatory signal inhibitor
adalimumab - TNF inhibitor
azathioprine - Purine synthesis inhibitor
chloroquine and hydroxychloroquine (antimalarials) - Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and decrease chemotaxis
ciclosporin (Cyclosporin A) - calcineurin inhibitor
D-penicillamine - Reducing numbers of T-lymphocytes etc.
etanercept - decoy TNF receptor
golimumab - TNF inhibitor
gold salts (sodium aurothiomalate, auranofin) - unknown
infliximab - TNF inhibitor
leflunomide - Pyrimidine synthesis inhibitor
methotrexate (MTX) - Purine metabolism inhibitor
minocycline - 5-LO inhibitor
rituximab - chimeric monoclonal antibody against CD20 on B-cell surface
sulfasalazine (SSZ) - Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors

Immunotherapy and cancer

Immunotherapy involves training the immune system to both better recognize cancer cells and attack them so that cancer becomes nothing more than a chronic condition. From Citi's Andrew Baum: "While existing chemotherapy or even newer oral drugs have a powerful initial effect on tumor shrinkage (the so called "response rate"), the durability of these responses are typically very short, after which the tumor begins to grow again and starts to spread (metastasize). In contrast, the durability of responses with immunotherapy can last a decade or longer, due to the induction of an ongoing immunological memory, targeting cancer cells for an indeterminate length of time and making it a potential tool to transform a significant percentage of cancers into something akin to a chronic disease."

Insane stat: Two-thirds of Western cancer incidence could be successfully treated with immunotherapy.

California Institute for Regenerative Medicine National Institutes of Health Armed Forces Institute of Regenerative Medicine Advanced Cell Technology

- pixie dust, therapeutic powder made of exracellular matrix that activates adult stem cells already living in the body

Neuronal regeneration
GRP (glial-restricted precursors) with special signaling molecule produced GDA(glial-restricted precursor derived astrocyte) GDA cells could promote nerve growth while suppressing scar formation, allowing recovery to begin.