Lymphedema Framework

This site is strictly for information, please visit a certified professional before attempting anything. B-MECS is an acronym I use for solutions the current industry uses to deal with this chronic condition. This is knowledge and understanding at a doctoral level, see a doctor if you can. Higher level qualifications usually produce better results and less harmful effects.

Lymphedema from youtube .


Bandaging from youtube .

Manual lymphatic massage

Manual lymphatic massage from youtube .


Lymphedema exercises for arm from youtube .

Lymphedema exercises for leg from youtube .


Skin care

Lymphedema skin care from youtube .

For a great starting place to develop expertise for immunology and its physiological effects on the body you should see this free course from UC Irvine. I am very pleased with this course and the fact it's free. immunology and hematology . Once you understand the concepts from this course then you should be able to figure out how to get into the future alternatives.

Future alternatives

Growth factor therapy

Growth Factor Primary activity
PDGF promotes proliferation of connective tissue, glial and smooth muscle cells
EGF promotes proliferation of mesenchymal, glial and epithelial cells
TGF-alpha may be important for normal wound healing
FGF promotes proliferation of many cells; Inhibits some stem cells; induces mesoderm to form in early embryos
NGF promotes neurite outgrowth and neural cell survival
Erythopoietin promotes proliferation and differentiation of erythrocytes
TGF-beta anti-inflammatory (suppresses cytoline production and MHC2 expression), promotes wound healing, inhibits macrophage and lymphocyte proliferation
IGF-I promotes proliferation of many cell types
IGF-II promotes proliferation of many cell types primarily of fetal origin

Tumour EGFR Expression Rate %
Breast 14-91
Colon 25-77
Lung Cancer
(Non small cell)
Head and Neck 80-95
Ovarian 35-70
Pancreatic 30-50

Available drugs

Gefitinib - Highly selective, potent and reversible
Erlotinib - EGFR Tyrosine kinase Inhibitor
Cetuximab - Monoclonal Anti EGFR antibody
H 447 - Bispecific Anti EGFR antibody
MDX 210 - linked to Anti CD 64

Growth factors with Oncogenic Potential

Other viral oncogenes encoded protein products that were growth factors that often overexpressed in cancer such as TGF-a.
PDGF family : A chain, B chain (c-sis)
FGF family : acidic FGF, basic FGF
EGF family : EGF, TGF-a
Neurotrophins : NGF, BDNF, NT3
Cytokines (Hematopoietic) : IL-2, IL-3, M-CSF, GM-CSF

EGFR stimulation and dimerisation - Hetero Dimerisation (HER1-EGFR and HER2-neu) = risk for cancer

Genetic therapy

To create and develop vaccine quality control I started a discussion group on LinkedIn called Dynamic Systemic Architecture. Vaccines are absolutely needed they deal with the fatal (death) situations but our current approaches are static solutions applied to dynamic environments. It's pretty much impossible to come up with perfect solutions.
Vaccines will have side effects (chickenpox - shingles) but don't forget they were absolutely needed. You're not helping anyone by getting mad or suing companys. Lets put our energy and efforts and try to come up with better solutions or cures. Go to LinkedIn and join the Dynamic Systemic Architecture group.

For comments, collaboration, and etc: Contact or email to

Naked plasmid DNA.
Genetic immunization is a simple method for eliciting an immune response.
DNA-coated gold microprojectiles - Biorad - Helios Gene Gun.
DNA Vaccines

Vaccinate ourselves using mini-gene guns and disposable DNA vaccine cartridges - by Powderject

100x Higher affinity antibodies than conventionally developed antibodies - higher avidity. By Genovac

pAlliance - contract manufacturing of therapeutic plasmid DNA

DNA Vaccines - Manufacture
-Process development andd QC issues
-Cell origin, genotype and phenotype
-Genetic stability (WCB)
-Source of process components
-Process contaminants in final product
-Adventitious agents (e.g. baceriophage) in MCB and WCB
-Genetic charactization
-Verify DNA sequence of entire vaccine (vector plus insert) present in MCB

DNA Vaccines - Safety
-Local reactogenicity and systemic toxicity
-Nature of the immune response
-Tissue localization, persistence and integration
-Challenge/protection studies (demonstrate rationale for vaccine use)
-Prime/boost studies (support dose, schedule, route of each component)
-Cytokine expression (immunomodulation)

DNA Vaccines - Integration
-Potential Consequences of
-Genome instability
-Inactivation of specific genes (tumor suppressors)
-Activation of dominant oncogenes by insertion of promoters/enhancers
-Germline alteration

Guidance for Industry - Considerations for Plasmid DNA Vaccines for Infectious Disease Indications
US Department of Health and Human Services
US Food and Drug Administration (FDA)
Center for Biologics Evaluation and Research (CBER)

Expression Library Immunization (ELI) - Stephen Johnston
University of Texas Southwestern Medical Centre, Dallas
-Clone the DNA of a pathogen into groups of about 1000 plasmids.
-Inject mice with each group and challenge.
-Select the group that conferred protection, break it into groups of 100 and re-examine.
-Repeat this process to the level of single plasmid.
-From the library, one can thus identify a few plasmids that can confer protection.

Immunostimulatory effects of CpG motifs
-Immunostimulatory DNA sequences necessary for effective intradermal gene immunization.
-CpG containing oligos augment antigen-specific serum antibody levels upto ten fold and IFNg production upto six fold.
-Unmethylated CpG in particular sequence contexts, are recognized as foreign by the innate immune system.
-They activate macrophages, induce B cell proliferation and stimulate strong B cell responses.
-They are as effective as Freund's complete adjuvant.
-They can act synegistically with other adjuvants such as alum.

DNA vaccines can also be Oral, or touch (skin)
Equine Health Solutions - West Nile-Innovator DNA
Apex IHN - prevent Infectious Haematopoietic Necrosis (IHN) in salmon.
Inovio - Pennvax family of vaccines - for cervical cancer, avian influenza, universal influenza, HIV prevention, HIV therapeutic, prostate cancer, hepatitis C virus, Breast/Lung/Prostate

My career as a COTA has lead me to develop expertise in various subjects. Lymphedema, arthritis, cognition, dementia with emphasis on alzheimer's, and neuormuscular disorders have been my subjects of interest. Lymphedema is just where I decided to start to develop my expertise with cancer therapys. This site is strictly for information purposes, please see a certified professional before doing anything.
Vaccines will have side effects (chickenpox - shingles) but don't forget they were absolutely needed. You're not helping anyone by getting mad or suing companys. Lets put our energy and efforts and try to come up with better solutions or cures. Go to LinkedIn and join the Dynamic Systemic Architecture group.

Associations of infection with autoimmunity
infection HLA asssociation Consequence
Group A Streptococcus Not known Rheumatic fever, carditis, polyarthritis
Chlamydia trachomatis HLA-B27 Reiter's syndrome (arthritis)
Shigella flexneri
Salmonella typhimurium
Salmonella enteritidis
Yersinia enterocolitica
Campylobacter jejuni
HLA-B27 Reactive arthritis
Borrelia burgdorferi HLA-DR2, DR4 Chronic arthritis in Lyme disease
Coxsackle A virus,
Coxsackle B virus,
Type 1 diabetes

Animal model for AI: Experimental Autoimmune Encephalomyelitis (EAE) - model for MS (Multiple Sclerosis)

I have been pleased to have been allowed to take on serving roles for other people, it has been a rewarding experience for me.

COTA Career Navy Information Technlogy Consultant